Botswana: On 25 March 2025, Botswana's Ministry of Health reported a significant increase in malaria cases reported in the past four weeks, related to recent heavy rains. This outbreak, which began in Okavango, has spread to several other districts. There have also been reports of cases in non-endemic areas, including Francistown, Gaborone, Mahalapye and Serowe.

Namibia: As of March 9, 2025, over 20,000 malaria cases have been reported. The most affected regions include the Caprivi Strip (particularly the cities of Katima Mulilo and Andara), areas along the Okavango River, and regions near the Angolan border, such as Outapi in the Omusati province, Eenhana and Okongo in the Ohangwena province, Nkurenkuru in the Kavango West province, and Nyangana in the Kavango East province.